The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
February 23, 2016
Research in Dr. Chen’s laboratory is directed towards understanding the structure/function relationships and physiological roles of the calcium release channel (ryanodine receptor) (RyR) in cardiac function. His current research interests focus on: (i) the molecular and cellular basis of cardiac arrhythmia and sudden death (ii) the molecular actions of pro- and anti-arrhythmic drugs and the development of novel anti-arrhythmic therapies (iii) the molecular mechanisms of RyR activation by cytoplasmic and luminal calcium (iv) regulation of RyR by phosphorylation, calmodulin and other protein regulators (v) three-dimensional structure of RyR Techniques used in his studies include site-directed mutagenesis, single channel recordings in planar lipid bilayers, fluorescence Ca^2+ imaging, purification of recombinant RyR proteins for biochemical and structural studies, cryo-electron microscopy, and gene targeting in mice.
Dr. Chen will give the James O. Davis Distinguished Lecture at the Reynolds Alumni Center starting at 11am on Tuesday, Feburary 23, 2015. “The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.” Registration2016